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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Formulation and Evaluation of Propanolol HCl Controlled Porosity Osmotically Controlled Tablet
R. Sakthikumar*, R. Lathaeswari, R. Senthamarai, T.N.K. Suriyaprakash and A. Anithaa
Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences, K. Sathanoor Main Road, Tiruchirapalli-620021
The objective of the present study is to formulate once daily controlled porosity osmotic tablet of Propanolol HCl for the treatment of Hypertension and to reduce the pill burden by avoiding dosing frequency. Controlled porosity osmotic tablets have an advantage of avoiding cost and labor. Six batches (F1-F6) of osmotic tablets were made with Mannitol, KCl and NaCl as osmotic agent by wet granulation technique. The granules were evaluated for precompression properties. The granules were compressed into tablet using Rotary tablet compression machine. The tablets were coated with Ethyl Cellulose (F1E-F6E) and Cellulose Acetate (F1C-F6C) as coating polymer i.e. semipermeable membrane. The tablets were subjected to evaluation parameters like weight variation, hardness, friability, % weight increase for coated tablet and in-vitro dissolution using USP Type I apparatus. All batches compiles with pharmacoepial standards. Among the twelve batches F5C showed sustained release over a period of 20 hrs with 80.59% drug release. The best formulation was subjected to stability studies for 3 months 45°C and 70% RH.
Propanolol HCl, Controlled porosity osmotic tablet, Ethyl Cellulose, Cellulose Acetate.
R. Sakthikumar, R. Lathaeswari, R. Senthamarai, T.N.K. Suriyaprakash, A. Anithaa. Formulation and Evaluation of Propanolol HCl Controlled Porosity Osmotically Controlled Tablet. Research J. Pharma. Dosage Forms and Tech. 2010; 2(6): 378-380.
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