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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Formulation and Evaluation of Lipid Microspheres of Ketoprofen
Ramesh Babu H.V
Preethi Sudheer*, Ramesh Babu H.V and Soosamma John
East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049.
Lipid microspheres of ketoprofen was prepared by emulsification method using waxes such as bees wax, carnauba wax and cetosteryl alcohol. These microspheres were evaluated for in-vitro dissolution studies, thin layer chromatography, scanning electron microscopy and particle size analysis. Lipid microspheres were studied for diffusion characteristics using cellophane membrane and permeation characteristics through excised rat abdominal skin. Lipid microspheres were found to increase the rate of permeation of poorly absorbable ketoprofen, so they may be used as a potential carrier in increasing the rate of absorption in case of topical delivery of drugs.
Lipid microspheres, ketoprofen, emulsification, diffusion
Preethi Sudheer, Ramesh Babu H.V, Soosamma John. Formulation and Evaluation of Lipid Microspheres of Ketoprofen. Research J. Pharma. Dosage Forms and Tech. 2010; 2(5): 340-343 .
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