Volume No. :   2

Issue No. :  4

Year :  2010

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Formulation and Evaluation of Nicorandil Chewing Gum



Address:   Yashaswini P M*, Someshwara Rao B, Ranjit Kumar P, Vinod R, Suresh V Kulkarni, Ashok Kumar P.
Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, India.
*Corresponding Author
DOI No:

ABSTRACT:
The study was to formulate and evaluate medicated chewing gum of Nicorandil, a novel potassium channel opener used in cardiovascular diseases. The chewing gums were prepared by direct compression method using different ratio of directly compressible gum base (pharmagum-M) in order to obtain new formulation. Eight different formulations of chewing gums of Nicorandil were prepared, which contains various concentration of pharmagum M. The chewing gums which are prepared by direct compression method were characterized by pre compression characters, post compression character, buccal absorption study, drug content, and in vitro drug release studies. All the formulations gave satisfactory results in terms of pre compression characters, post compression character, buccal absorption study, drug content, and in vitro drug release. The best compression characters and in vitro drug release profile were achieved in formulations F4, F5 and F6 with a gum concentration of 84%, 86% and 88% respectively.
KEYWORDS:
Chewing gum, Buccal absorption, Nicorandil, Pharmagum M, Sorbitol
Cite:
Yashaswini P M, Someshwara Rao B, Ranjit Kumar P, Vinod R, Suresh V Kulkarni, Ashok Kumar P. Formulation and Evaluation of Nicorandil Chewing Gum. Research J. Pharma. Dosage Forms and Tech. 2010; 2(4): 301-306 .
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