Volume No. :   2

Issue No. :  3

Year :  2010

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Design and Evaluation of the Fast Dissolving Tablets of Aceclofenac by Sublimation Technique



Address:   Sumanta Malakar, Ashok Kumar P.*, Suresh V. Kulkarni, Someshwara Rao B., Amit S. Yadav
Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, India.
*Corresponding Author:
DOI No:

ABSTRACT:
The purpose of this study was to formulate and evaluate fast dissolving tablet of aceclofenac by sublimation technology using camphor. Sodium starch glycolate and crospovidone were used as superdisintegrants. Tablets were prepared by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density and compressibility index. Tablets were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro dispersion and in vitro dissolution. In vitro release studies were performed using USP XXII dissolution apparatus type II (Electro lab, Mumbai, India) paddle method in 900 ml of pH-7.4 at 75 rpm. Among all the formulation, F-6 shows 83.26% release at the end of 22 min. Thus, F-6 was considered as the best among the other formulations. The selected formulation F-6 was subjected to stability studies for three months, which showed stability with respect to release pattern.
KEYWORDS:
Aceclofenac, Sodium starch glycolate, Crospovidone, Fast dissolving tablets.
Cite:
Design and Evaluation of the Fast Dissolving Tablets of Aceclofenac by Sublimation Technique. Sumanta Malakar, Ashok Kumar P., Suresh V. Kulkarni, Someshwara Rao B., Amit S. Yadav. Research J. Pharma. Dosage Forms and Tech. 2010; 2(3):233-236 .
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