Volume No. :   2

Issue No. :  2

Year :  2010

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Enhancement of Solubility of Poorly Water Soluble Drug (Allopurinol) Through Solid Dispersion



Address:   Chirag A. Patel1, Priyal R. Patel1, Dhrubo Jyoti Sen2 and Jayvadan K. Patel3
1Department of Pharmaceutics, S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-Gozaria Highway, Kherva-382711, Ta. and Dist: Mehsana (N.G.)
2Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Mehsana-384001, Gujarat
3Department of Pharmaceutics, Nootan Pharmacy College, Visnagar-384315, Gujarat
*Corresponding Author:
DOI No:

ABSTRACT:
The present study is to enhance the solubility of poorly water soluble drug by using different techniques like solid dispersion and crystal formation and selected drug was allopurinol. Allopurinol is poorly water soluble drug (which has solubility 0.1mg/ml) used in treatment of gout. Rapid onset of action of allopurinol drug in treatment of gout is required. Solubility is rate limiting step for this drug. So, by enhancing the solubility we can improve the bioavailability of poorly water soluble drug. For solubility enhancement we used different polymer like PEG4000, PVPK30, poloxamer 127 grade in solid dispersion. And in crystal formation used the different 11 solvent among them only ethanol, ether, and (dimethyl sulfoxide) DMSO has found good solubility and dissolution rate. For selection of solvent and polymer we had checked the compatibility by using (Differential Scanning Colorimeter) DSC And (Infra Red Spectroscopy) IR, and proved that used solvent which compatible with drug. For preparation of solid dispersion we were used melting method and solvent evaporation method. And then prepared solid dispersion carried out for scanning electron microscope) SEM study for surface property of solid dispersion. Checked the solubility and disintegrating time. Final formulation was prepared tablet dosage form after optimized batch of solid dispersion and take dissolution of tablet. All tablet prepared from solid dispersion, crystal and marketed were compare by dissolution study .and finally concluded the tablet prepared by solid dispersion is best than others.
KEYWORDS:
Allopurinol, Solubility, Solid Dispersion, Crystal
Cite:
Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel. Enhancement of Solubility of Poorly Water Soluble Drug (Allopurinol) Through Solid Dispersion. Research J. Pharma. Dosage Forms and Tech. 2010; 2(2):156-163 .
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