Volume No. :   2

Issue No. :  2

Year :  2010

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Chronopharmaceutics: A Clinically Relevant Approach to Drug Delivery



Address:   Gaurav Tiwari2*, Awani K Rai1, Vachaspati Dubey1, Anil Sharma3, Pranay Wal1 and Ankita Wal1
1Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), India
2Jaipur National University, Jagatpura, Jaipur, Rajasthan
3Suresh Gyan Vihar University, Jaipur, Rajasthan
*Corresponding Author:
DOI No:

ABSTRACT:
Chronopharmaceutics covers the fundamentals of the various aspects of chronopharmaceutics in the fields of chronobiology, chronogenetics, chronophysiology, chronopathology, chronopharmacology, chronotherapeutics, chronotoxicology and chronobiotics, and chronopharmaceutical drug delivery research. It discusses different and specific controlled-release systems that are triggered by electrics, diffusion, and chemical-activation and concludes with a description of the regulatory issues along with formulation and manufacturing.Due to advances in chronobiology, chronopharmacology, and global market constraints, the traditional goal of pharmaceutics (e.g. design drug delivery systems with a constant drug release rate) is becoming obsolete. However, the major bottleneck in the development of drug delivery systems that match the circadian rhythm (chronopharmaceutical drug delivery systems: ChrDDS) may be the availability of appropriate technology. The last decade has witnessed the emergence of ChrDDS against several diseases. The increasing research interest surrounding ChrDDS may lead to the creation of a new subdiscipline in pharmaceutics known as chronopharmaceutics. This review introduces the concept of chronopharmaceutics, addresses theoretical/formal approaches to this sub-discipline, underscores potential disease-targets, revisits existing technologies and examples of ChrDDS. Future development in chronopharmaceutics may be made at the interface of other emerging disciplines such as system biology and nanomedicine. Such novel and more biological approaches to drug delivery may lead to safer and more efficient disease therapy in the future.
KEYWORDS:
Chronopharmaceutics; Chronopharmacology; Chronotherapeutics; Drug Delivery; Technologies
Cite:
Gaurav Tiwari, Awani K Rai, Vachaspati Dubey, Anil Sharma, Pranay Wal, Ankita Wal. Chronopharmaceutics: A Clinically Relevant Approach to Drug Delivery. Research J. Pharma. Dosage Forms and Tech. 2010; 2(2):139-145.
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