Volume No. :   2

Issue No. :  2

Year :  2010

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Preparation and Evaluation of Floating Calcium Alginate Beads of Clarithromycin



Address:   SM Sarode*1, G Vidya Sagar2, MK Kale1, Nimase PK3, Kulkarni AP1, Firke SD1,Firke BM1, Warke PD1 and Chaudhari MA1
1K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.)
2Veerayatan Institute of Pharmacy, Bhuj, Gujrat.
3Smt.S.S.Patil college of Pharmacy, Chopda (M.S.)
*Corresponding Author
DOI No:

ABSTRACT:
The objective of this investigation was to develop an intra gastric floating drug delivery system of clarithromycin and also attempts were made to sustain the release of clarithromycin. Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing Hydroxypropylmethylcellulose (K100M) and sunflower oil by using emulsion-gelation method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below two minutes and shows total floating duration more than ten hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing two percent sodium alginate solution and five percent calcium chloride solution along with 500mg HPMC and five ml sunflower oil (i.e.F14) and also the result of in-vitro dissolution studies reveals that the formulation F14 gave sustained release pattern of clarithromycin upto 12 hrs.
KEYWORDS:
Floating alginate beads; emulsion gelation; clarithromycin; controlled release.
Cite:
SM Sarode, G Vidya Sagar, MK Kale, Nimase PK, Kulkarni AP, Firke SD,Firke BM, Warke PD, Chaudhari MA. Preparation and Evaluation of Floating Calcium Alginate Beads of Clarithromycin. Research J. Pharma. Dosage Forms and Tech. 2010; 2(2):173-177 .
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