Volume No. :   2

Issue No. :  1

Year :  2010

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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A Brief Review on Gastro Retentive System



Address:   Dahake MN, Wattamwar PP, Bongirwar RA, Mohale DS, Bakal RL and Chandewar AV
P.Wadhwani College of Pharmacy, Yavatmal (M.S.) India
*Corresponding Author
DOI No:

ABSTRACT:
Oral delivery of drug is the most preferable route of drug delivery due to ease of administration, patient compliance and flexibility in formulation etc. However, it is a well accepted fact that it is difficult to predict the real in vivo time of release with solid, oral controlled release dosage forms. Various attempts have been made to prolong the retention time of the dosage form in the stomach. One such approach is development of floating Microspheres involves preparation of a device that remains buoyant in the stomach contents due to its lower density than that of the gastric fluids.Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. These microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. Floating microspheres are specially gaining attention due to their wide applicability in the targeting of drugs to stomach.
KEYWORDS:
Oral controlled release dosage form, retention time, floating microsphere.
Cite:
Dahake MN, Wattamwar PP, Bongirwar RA, Mohale DS, Bakal R, Chandewar AV. A Brief Review on Gastro Retentive System. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1):28-31.
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