Volume No. :   2

Issue No. :  1

Year :  2010

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Transdermal Drug Delivery System of Salbutamol Sulphate: Formulation and Evaluation



Address:   Vaseeha Banu T. S.1*, Sukhen Som2, Mohamed Khaleel2 and Nirmal T. Havannavar2
1Department of Pharmaceutics, M.M.U College of Pharmacy, K. K. Doddi, Dist- Ramanagara- 571511, Karnataka (India)
2Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K. K. Doddi, Dist. Ramanagara- 571511, Karnataka (India)
*Corresponding Author
DOI No:

ABSTRACT:
Salbutamol Sulphate (SS) is a selective ß2 adrenergic receptor agonist having oral bioavailability of 50%. The transdermal films of SS were formulated using solvent casting technique. Solutions containing polymers i.e. Hydroxy Propyl Methyl Cellulose (HPMC) and Ethyl Cellulose (EC) at different concentrations (1%, 1.5%, 2%, 2.5%, and 3%) were prepared. These solutions were then used to prepare films. Prepared films were then evaluated for their different physicochemical parameters like physical appearance, weight variation, thickness, drug content, folding endurance, tensile strength, percent elongation and finally in vitro release study across rat abdominal skin. Between the two polymers used results revealed that the films prepared by using 2% HPMC with 30% propylene glycol(PG) was very flexible with high folding endurance and uniform drug content, further release study showed 88.68% release across the rat abdominal skin for 24 hours.
KEYWORDS:
Salbutamol, Asthma, Bronchitis
Cite:
Vaseeha Banu T. S., Sukhen Som, Mohamed Khaleel, Nirmal T. Havannavar. Transdermal Drug Delivery System of Salbutamol Sulphate: Formulation and Evaluation. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1):56-61
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