Volume No. :   1

Issue No. :  3

Year :  2009

ISSN Print :  0975-234X

ISSN Online :  0975-4377


Registration

Allready Registrered
Click to Login

Studies on Occlusion Complexes of Aceclofenac with β-Cyclodextrin and Hydroxypropyl -β- Cyclodextrin



Address:   Patil GB*1, Deshmukh PK2 and Belgamwar VS1
1Department of Pharmaceutics, R.C.Patel College of Pharmacy, Near Karwand Naka, Shirpur, Dist-Dhule-425405, Maharashtra, India.
2H.R.Patel Women’s College of Pharmacy, Near Karwand Naka, Shirpur, Dist-Dhule-425405, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
The present study is aimed at improving the dissolution of poorly water soluble Aceclofenac by complexation with ß-cyclodextrin and Hydroxypropyl-ß-cyclodextrin. Bioavailability of such drug may be enhanced by improving its solubility and dissolution rate. The objective of present study is to increase the solubility and dissolution rate of Aceclofenac by preparing its occlusion complexes with ß-cyclodextrin and Hydroxypropyl-ß-cyclodextrin in different molar ratios using kneading method. The prepared complexes were characterized for drug content, differential scanning calorimetry, FTIR spectral studies, phase solubility and in-vitro dissolution profile. DSC and FTIR spectral studies performed on solid complexes have confirmed the inclusion complexation between drug and Cyclodextrins. It has been observed that solubility and dissolution rate increased to greater extent for Hydroxypropyl-ß-cyclodextrin than ß-cyclodextrin and that of pure drug.
KEYWORDS:
Aceclofenac, β-cyclodextrin, Hydroxypropyl-β-cyclodextrin, Inclusion complex, DSC, FTIR, solubility, Dissolution Enhancement.
Cite:
Patil GB, Deshmukh PK, Belgamwar VS. Studies on Occlusion Complexes of Aceclofenac with β-Cyclodextrin and Hydroxypropyl -β- Cyclodextrin. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):200-203.
[View HTML]      [View PDF]



Visitor's No. :   136797