Volume No. :   1

Issue No. :  3

Year :  2009

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Design, Development and in-vitro evaluation of Herbal Matrix tablet



Address:   NM Bhopale*, HS Sawarkar1, MB Narkhede1, NV Thorat1, MR Bhise1 and SS Khadabadi2
1I.B.S.S. College of Pharmacy, Malkapur- 443 101 (M.S.)
2 Govt. College of Pharmacy, Amravati-444 603 (M.S.)
*Corresponding Author
DOI No:

ABSTRACT:
The purpose of the present investigation was to develop the sustain release matrix tablet of Tinospora cordifolia using the various polymers like HPMC (Hydroxy-Propyl-methyl-cellulose), Ethyl cellulose (EC), of different viscosity grade. Ethanolic extract of Tinospora cordifolia was used for the formulation of sustain release matrix tablet and tablet formulations were developed by using wet granulation method. Different diluents like lactose, magnesium stearate and cab-o-sil were used for improving flowability and compressibility. Binder such as polyvinyl pyrrolidone was used for optimization of the formulations. Sodium starch glycolate was used as disintegrating agent. Pre and post formulation parameters were studied for all the batches. HPMC –KM4 shows better result for matrix tablet in terms of sustain drug release with comparison to different viscosity grade of HPMC and ethyl cellulose. The dissolution study of the Tinospora cordifolia tablets exhibited 99.54% release of total polyphenol.
KEYWORDS:
Ethanolic extract of Tinospora cordifolia, HPMC, Ethyl cellulose, Matrix tablet.
Cite:
NM Bhopale, HS Sawarkar, MB Narkhede, NV Thorat, MR Bhise, SS Khadabadi. Design, Development and in-vitro evaluation of Herbal Matrix tablet. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):254-256.
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