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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Development and Evaluation of Topical Microemulsion Gels for Protein and Peptide Drug Bacitracin Zinc
Deelip V Derle
Devendra R Yeole
Deelip V Derle*,, Sagar BSH and Devendra R Yeole
Department of Pharmaceutics, N.D.M.V.P. Samaj’s, College of Pharmacy, Nashik– 422002, Maharashtra, India.
The present study deals with the preparation of topical microemulsion gels of bacitracin zinc an antibacterial agent, with an aim to increase its penetration capacity and there by its efficiency. Microemulsions with varying weight ratios of surfactant to cosurfactant were prepared using oleic acid as oil, tween 80 as surfactant, ethylene glycol/propylene glycol as cosurfactants and saline. The area of the microemulsion region increased with increasing ratios of surfactant/cosurfactant. The mean diameter of the microemulsions was carried out using coulter counter. The size of the systems formed were 87± 2 and 61± 4 nm. For the final study four formulations were chosen out of which two are microemulsions gels and the rest were microemulsion-based gels. The rheological behaviour of prepared systems revealed that gels were pseudoplastic due to the intermolecular interactions between polymeric chains. The in vitro drug release was carried out in pH 7.0 phosphate buffer on excised human cadaver skin using Keshary-Chien diffusion cell for 24 hours and was compared with a marketed formulation. The results showed that release of drug from F4 was found to be 89.33% as compared to 58.05% from marketed and microemulsion based gels.
Bacitracin zinc, Microemulsons, Oleic acid, Tween 80.
Deelip V Derle, Sagar BSH , Devendra R Yeole. Development and Evaluation of Topical Microemulsion Gels for Protein and Peptide Drug Bacitracin Zinc. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):217-221.
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