Volume No. :   1

Issue No. :  3

Year :  2009

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Development and Characterization of a Stable Suspension of Rifampicin and Isoniazid



Address:   AM Avachat1* and SB Bhise2
1Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune, 411 041, Maharashtra, India
2Govt. College of Pharmacy, Karad, 415124, Maharashtra, India
*Corresponding Author
DOI No:

ABSTRACT:
Rifampicin (RMP) and Isoniazid (INH) are highly unstable in liquid dosage form and there is no liquid product available. A novel concept of formulating a suspension of RMP and INH for pediatric and geriatric application has been tried. The reconstitutable dry syrup which can be reconstituted by using a special vehicle has shown very good stability at 2-80C and at 250C for more than 1 month and 14 days respectively using a stability indicating HPLC method. The in vitro dissolution studies have revealed no adverse impact of special vehicle on dissolution. Thus this combination product could prove to be a major boost for the market need for pediatric patients.
KEYWORDS:
Rifampicin, Isoniazid, suspension, stability
Cite:
AM Avachat, SB Bhise. Development and Characterization of a Stable Suspension of Rifampicin and Isoniazid. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):213-216.
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