Volume No. :   1

Issue No. :  2

Year :  2009

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188



Address:   DS Saindane*1, AS Kulkarni, AN Sagri, RB Pimprikar2, SB Yeshwante2, CP Suryawanshi2, SD Firke3, MK Kale3
1Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.)
2 Gangamai College of Pharmacy, Nagaon, Dhule(M.S.)
3 KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.)
*Corresponding Author
DOI No:

ABSTRACT:
This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in poloxamer 188 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:Poloxamer 188 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and Poloxamer 188 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. The amorphous state of CFX coupled with presence of interaction between drug and Poloxamer 188. However, the antimicrobial activity of CFX was increased significantly by Poloxamer 188 against S. aureus and E. coli. The solid dispersion technique of CFX:Poloxamer 188 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.
KEYWORDS:
Cefixime; Solid dispersion; Poloxamer 188; Freeze drying; Dissolution rate; Binary system
Cite:
DS Saindane, AS Kulkarni, AN Sagri, RB Pimprikar, SB Yeshwante, CP Suryawanshi, SD Firke, MK Kale. Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 162-166.
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