Volume No. :   1

Issue No. :  2

Year :  2009

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Design and Evaluation of Mucoadhesive Tablets of Lorsatan Potassium

Address:   V Ganesan1, Nilesh P Tekade2*, Nitin S Bhajipale2, Durgesh R Dewade2 and Raju R Thenge3
1Swami Vivekananda College of Pharmacy, Elayampalayam-637 205, Tiruchengode, Namakkal, Tamilnadu
2S.G.S.P.S. Institute of Pharmacy, Kaulkhed, Akola 444004, Maharashtra, India.
3I.B.S.S College of Pharmacy, Malkapur 443101, Buldana, Maharashtra, India.
*Corresponding Author

Mucoadhesive tablets of Lorsatan Potassium were prepared using carbopol-940P, Sodium carboxy methyl cellulose (SCMC), hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC) and Eudragit-RL100 as mucoadhesive polymers. Eight formulations were developed with varying concentrations of polymers. The SCMC is used as a primary polymer because of its excellent mucoadhesive property and secondary polymers like HPMC, EC, Carbopol-940P and Eudragit RL-100 were used. The formulations were evaluated for in-vitro drug release, in-vitro swelling studies and in-vitro bioadhesive strength studies. Formulation R-03 showed maximum release of 95.68% in 10hours and maximum swelling index of 99.59 % after 10hours, also showed highest bioadhesion. FTIR studies show no evidence on interaction between drug and polymers. The results indicate that suitable mucoadhesive tablets with desired properties could be prepared.
Mucoadhesive tablets, Losartan Potassium, Swelling index, FT-IR, Drug release
V Ganesan, Nilesh P Tekade, Nitin S Bhajipale, Durgesh R Dewade, Raju R Thenge. Design and Evaluation of Mucoadhesive Tablets of Lorsatan Potassium. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 139-142.
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