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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Formulation and In-Vitro Evaluation of Fast Dissolving / Disintegrating Tablets of Tizanidine Hydrochloride
Rahul K. Godge
Prakash N. Kendre
Mahendra A. Giri
Syed M. Zama
Syed N. Lateef
Rahul K. Godge, Prakash N. Kendre, Mahendra A. Giri, Syed M. Zama, Syed N. Lateef*
Sanjivani College of Pharmaceutical Education and Research, Kopargaon Dist. Ahmadnagar.(M.S.) India.
Tizanidine hydrochloride, the first new oral treatment for muscle spasticity in the U.S. in more than 20 years. Fast dissolving tablets are solid dosage form that contains medicinal substances and that disintegrate and dissolve rapidly without water (within seconds) when placed on the tongue. Fast dissolving tablets of Tizanidine hydrochloride were prepared by direct compression method using Sodium Starch Glycolate, Ac-Di-Sol, and Indion 414 as a super disintegrants, and controlled tablets without any super disintegrant and evaluated for hardness, friability, disintegration time, dissolution time, water absorption ratio and content uniformity. All tablets containing super disintegrants shows release of drug more than 95% within 10 minutes and controlled tablet shows release of drug after 30 minutes. Tablets containing Indion 414 as a super disintegrant shows better result compare to others. Result also shows that as the concentration of superdisintegrant increases percentage release also increases.
Fast dissolving tablet, Direct compression, Tizanidine hydrochloride.
Rahul K. Godge, Prakash N. Kendre, Mahendra A. Giri, Syed M. Zama, Syed N. Lateef. Formulation and In-Vitro Evaluation of Fast Dissolving / Disintegrating Tablets of Tizanidine Hydrochloride. Research J. Pharma. Dosage Forms and Tech. 2009; 1(1):55-58.
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